Characterization of cholecystokinin octapeptide-stimulated endogenous dopamine release from rat nucleus accumbens in vitro
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چکیده
منابع مشابه
Effect of cholecystokinin-octapeptide on dopamine release from slices of cat caudate nucleus.
The cat caudate nucleus has been reported to possess a rich and fairly even distribution of nerve endings, containing both dopamine- and cholecystokinin-like peptides. In this study, the effect of cholecystokinin-octapeptide (CCK-8) on basal and electrically evoked tritium outflow from slices of cat caudate nucleus previously labeled with [3H]dopamine was examined. Evoked tritium outflow from s...
متن کاملA thyrotropin releasing hormone analog, DN-1417, increases endogenous dopamine release from slices of rat striatum and nucleus accumbens.
Besides its hormonal effects, thyrotro pin releasing hormone (TRH) induces se veral behavioral changes in rats. Marked increases in locomotor activity occur after administration of TRH and its analogs. This effect was hypothesized to be due to a stimulation of mesolimbic dopaminergic neurons (Miyamoto and Nagawa, 1977; Heal and Green, 1979). TRH has no effect on the reuptake of monoamines (Tuom...
متن کاملAlcohol promotes dopamine release in the human nucleus accumbens.
Microdialysis experiments in rodents indicate that ethanol promotes dopamine release predominantly in the nucleus accumbens, a phenomenon that is implicated in the reinforcing effects of drugs of abuse. The aim of the present study was to test the hypothesis in humans that an oral dose of ethanol would lead to dopamine release in the ventral striatum, including the nucleus accumbens. Six health...
متن کاملEffects of cannabinoids on dopamine release in the corpus striatum and the nucleus accumbens in vitro.
Cannabinoid receptors are widely distributed in the nuclei of the extrapyramidal motor and mesolimbic reward systems; their exact functions are, however, not known. The aim of the present study was to characterize the effects of cannabinoids on the electrically evoked release of endogenous dopamine in the corpus striatum and the nucleus accumbens. In rat brain slices dopamine release elicited b...
متن کاملEffects of nitrous oxide on dopamine release in the rat nucleus accumbens and expectation of reward.
Recently we have shown that nitrous oxide (N2O) was able to block the expression of morphine-induced conditioned place preference (CPP) in mice. Because dopamine (DA) has also been associated with the positive place conditioning we hypothesize that exposure to N2O would be significantly associated with a modification of extracellular level of DA. Unbiased place conditioning method was used for ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1990
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1990.tb13018.x